\score {
  <<
    \new Staff {
      \relative c''
      \new Voice = "vocal" {
        c d~^\markup default  d e
        c d~^\markup "right aligned" d e
        c d~^\markup "center aligned" d e
        c d~^\markup "reset to default" d e
      }
    }
    \new Lyrics \lyricsto "vocal" {
      word word word
      \set lyricMelismaAlignment = #RIGHT
      word word word
      \set lyricMelismaAlignment = #CENTER
      word word word
      \unset lyricMelismaAlignment
      word word word
    }
  >>
}